Naktyny






Struktury chemiczne antybiotyków jonoforowych należących do naktyn


Naktyny − grupa organicznych związków chemicznych, cykliczne poliestry będące antybiotykami jonoforowymi produkowanymi przez różne szczepy bakteryjne Actinomyces. Wykazują działanie przeciwbakteryjne, przeciwgrzybiczne, przeciwnowotworowe i inne.


Najprostszym związkiem z tej grupy jest nonaktyna, natomiast homologami nonaktyny są: monaktyna, dinaktyna, trinaktyna oraz tetranaktyna.



Bibliografia |



  • B. C. Pressman, ”Biological applications of ionophores”, Annu. Rev. Biochem. 1976, 45, 501-530.

  • G. D. J. Phillies, I. M. Asher, H. E. Stanley, ”Nonactin, monactin, dinactin, trinactin, and tetranactin. A Raman spectroscopic study”, Biopolymers, 1975, 14, 2311 – 2327.

  • M. Dobler, ”Natural Cation-binding Agents” w Molecular Recognition: Receptors for Cationic Guests G. W. Gokel (editor), 2004, ​ISBN 0-08-042713-8​, 267-313.



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p • d • e

Jonofory naturalne
Karboksylowe

  • jonomycyna

  • kalcymycyna

  • kwas lasalowy

  • laidlomycyna

  • monenzyna

  • narazyna

  • nigerycyna

  • salinomycyna

  • streptomycyna
Neutralne

  • beauwerycyna

  • enniatyny

  • fusafungina

  • gramicydyna D

  • gramicydyna S

  • naktyny

  • walinomycyna



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