Bleeding diathesis
| Bleeding diathesis | |
|---|---|
| Specialty | Hematology  |
In medicine (hematology), bleeding diathesis (h(a)emorrhagic diathesis) is an unusual susceptibility to bleed (hemorrhage) mostly due to hypocoagulability (a condition of irregular and slow blood clotting), in turn caused by a coagulopathy (a defect in the system of coagulation). Therefore, this may results in the reduction of platelets being produced and leads to excessive bleeding.[1] Several types of coagulopathy are distinguished, ranging from mild to lethal. Coagulopathy can be caused by thinning of the skin (Cushing's Syndrome), such that the skin is weakened and is bruised easily and frequently without any trauma or injury to the body.[2] Also, coagulopathy can be contributed by impaired wound healing or impaired clot formation.[3]
Contents
1 Symptoms
1.1 Complications
2 Causes
2.1 Acquired
2.2 Autoimmune causes of acquired coagulation disorders
2.3 Causes other than coagulation
3 Genetic
4 Diagnosis
4.1 Comparing coagulation tests
5 Treatments
6 References
7 External links
Symptoms
| Symptom | Disorders |
|---|---|
Petechiae (red spots) |
|
Purpura and ecchymoses |
|
Blood in stool |
|
| Bleeding gingiva (gums) |
|
| Prolonged nose bleeds |
|
Complications
Following are some complications of coagulopathies, some of them caused by their treatments:
| Complication | Disorders |
|---|---|
Soft tissue bleeding, e.g. deep-muscle bleeding, leading to swelling, numbness or pain of a limb. |
|
Joint damage, potentially with severe pain and even destruction of the joint and development of arthritis |
|
Retinal bleeding |
|
Transfusion transmitted infection, from blood transfusions that are given as treatment. |
|
Adverse reactions to clotting factor treatment. |
|
Anemia |
|
Exsanguination (bleeding to death) |
|
Cerebral hemorrhage |
|
Causes
While there are several possible causes, they generally result in excessive bleeding and a lack of clotting.
Acquired
Acquired causes of coagulopathy include anticoagulation with warfarin, liver failure, vitamin K deficiency and disseminated intravascular coagulation. Additionally, the haemotoxic venom from certain species of snakes can cause this condition, for example Bothrops, rattlesnakes and other species of viper. Viral hemorrhagic fevers include dengue hemorrhagic fever and dengue shock syndrome.
Leukemia may also cause coagulopathy. Furthermore, cystic fibrosis has been known to cause bleeding diathesis, especially in undiagnosed infants, due to malabsorption of fat soluble vitamins like vitamin K.
Autoimmune causes of acquired coagulation disorders
There are autoimmune causes of coagulation disorders. They include acquired antibodies to coagulation factors, termed inhibitors of coagulation. The main inhibitor is directed against clotting factor VIII. Another example is antiphospholipid syndrome, an autoimmune, hypercoagulable state.
Causes other than coagulation
Bleeding diathesis may also be caused by impaired wound healing (as in scurvy), or by thinning of the skin, such as in Cushing's syndrome.
Genetic
Some people lack genes that typically produce the protein coagulation factors that allow normal clotting. Various types of hemophilia and von Willebrand disease are the major genetic disorders associated with coagulopathy. Rare examples are Bernard-Soulier syndrome, Wiskott-Aldrich syndrome and Glanzmann's thrombasthenia. Gene therapy treatments may be a solution as they involve in the insertion of normal genes to replace defective genes causing for the genetic disorder. Gene therapy is a source of active research that hold promise for the future. [9]
Diagnosis
Comparing coagulation tests
| Condition | Prothrombin time | Partial thromboplastin time | Bleeding time | Platelet count |
|---|---|---|---|---|
Vitamin K deficiency or warfarin | Prolonged | Normal or mildly prolonged | Unaffected | Unaffected |
Disseminated intravascular coagulation | Prolonged | Prolonged | Prolonged | Decreased |
Von Willebrand disease | Unaffected | Prolonged or unaffected | Prolonged | Unaffected |
Haemophilia | Unaffected | Prolonged | Unaffected | Unaffected |
Aspirin | Unaffected | Unaffected | Prolonged | Unaffected |
Thrombocytopenia | Unaffected | Unaffected | Prolonged | Decreased |
Liver failure, early | Prolonged | Unaffected | Unaffected | Unaffected |
| Liver failure, end-stage | Prolonged | Prolonged | Prolonged | Decreased |
Uremia | Unaffected | Unaffected | Prolonged | Unaffected |
Congenital afibrinogenemia | Prolonged | Prolonged | Prolonged | Unaffected |
Factor V deficiency | Prolonged | Prolonged | Unaffected | Unaffected |
Factor X deficiency as seen in amyloid purpura | Prolonged | Prolonged | Unaffected | Unaffected |
Glanzmann's thrombasthenia | Unaffected | Unaffected | Prolonged | Unaffected |
Bernard-Soulier syndrome | Unaffected | Unaffected | Prolonged | Decreased or unaffected |
Factor XII deficiency | Unaffected | Prolonged | Unaffected | Unaffected |
C1INH deficiency | Unaffected | Shortened | Unaffected | Unaffected |
Treatments
Consult a hematologist and have a regular blood check ups. Have an early diagnostic test for any blood disorders or blood diseases including hemophilia, hemorrhage, and sickle-cell anemia. Prothrombin time and partial thromboplastin time blood tests are useful to investigate the reason behind the excessive bleeding. The PT evaluates coagulation factors I, II, V, VII and X, while the PTT evaluates coagulation factors I, II, V, VIII, IX, X, XI and XII. The analysis of both tests thus helps to diagnose certain disorders.[10]
Blood transfusion involves the transfer of plasma containing all the necessary coagulating factors (fibrinogen, prothrombin, thromboplastin) to help restore them and to improve the immune defense of the patient after excessive blood loss. Blood transfusion also caused the transfer of platelets that can work alongside with coagulating factors for blood clotting to commence.[11]
Different drugs can be prescribed depending on the type of disease. Vitamins (K, P and C) are essential in case of obstruction to walls of blood vessels. Also, vitamin K is required for the production of blood clotting factors, hence the injection of vitamin K (phytomenadione) is recommended to boost blood clotting.[12]
Herbal treatment is an alternative form of treatment which make use of plants to stimulate body's metabolism, stimulate blood coagulation and enhance tissue healing.
References
^ "Bleeding Diathesis: Causes, Symptoms, and Treatments". Doctors Health Press - Daily Free Health Articles and Natural Health Advice. 2017-06-23. Retrieved 2018-09-17..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
^ Douglas H (April 1949). "Cushing' Syndrome and Thymic Carcinoma". QJM: An International Journal of Medicine. 18 (2): 133–147. doi:10.1093/oxfordjournals.qjmed.a066529.
^ Amin C, Sharathkumar A, Griest A (2014-01-01). "Bleeding diathesis and hemophilias". Handbook of Clinical Neurology. 120: 1045–59. doi:10.1016/B978-0-7020-4087-0.00070-X. PMID 24365370.
^ abcde Wiskott-Aldrich Syndrome The International Patient Organisation for Primary Immunodeficiencies (IPOPI).
^ abcdefghi Disorders of thrombosis and hemostasis: clinical and laboratory practice. Page Rodger L. Bick. Edition 3, illustrated.
ISBN 0-397-51690-8,
ISBN 978-0-397-51690-2. 446 pages
^ abc Vitamin K Deficiency eMedicine. Author: Pankaj Patel, MD. Coauthor(s): Mageda Mikhail, MD, Assistant Professor. Updated: Dec 18, 2008
^ abcd Hemophilia Complications By Mayo Clinic staff. May 16, 2009
^ abcd Von Willebrand disease --> Complications By Mayo Clinic staff. Feb. 7, 2009
^ McCain J (June 2005). "The future of gene therapy". Biotechnology Healthcare. 2 (3): 52–60. PMC 3564347. PMID 23393464.
^ "Prothrombin Time (PT) w/INR and Partial Thromboplastin Time (PTT) Blood Test". Walk-In Lab. Retrieved 2018-09-17.
^ "Hemorrhagic diathesis: causes, symptoms, diagnosis, treatment | Competently about health on iLive". iliveok.com. Retrieved 2018-09-17.
^ "Treatments for bleeding disorders". Netdoctor. 2015-11-03. Retrieved 2018-09-17.
External links
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